Age-related risk factors and severity of SARS-CoV-2 infection: a systematic review and meta-analysis

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Age-related risk factors and severity of SARS-CoV-2 infection: a systematic review and meta-analysis

30, July 2021 |

Authors:

MOHAMMAD M. RAHMAN B. BHATTACHARJEE ZAKI FARHANA MOHAMMAD HAMIDUZZAMAN MUHAMMAD A.B. CHOWDHURY MOHAMMAD S. HOSSAIN MAHBUBUL H. SIDDIQEE MD. ZIAUL ISLAM ENAYETUR RAHEEM MD. JAMAL UDDIN

Abstract


Objectives. We aimed to estimate the prevalence of reported symptoms and comorbidities, and investigate the factors associ- ated with age of the SARS-CoV-2 infected patients. Methods. We performed a systematic review with meta-analysis (PROSPERO registration: CRD42020182677) where the data- bases (PubMed, SCOPUS, EMBASE, WHO, Semantic Scholar, and COVID-19 Primer) were searched for clinical studies pub- lished from January to April, 2020. Initially, the pooled preva- lence of symptoms and comorbidity of COVID-19 patients were estimated using random effect model and the age –related fac- tors were identified performing multivariate analysis [factor analysis]. Results. Twenty-nine articles with 4,884 COVID-19 patients were included in this study. Altogether, we found 33 symptoms and 44 comorbidities where the most frequent 19 symptoms and 11 comorbidities were included in the meta-analysis. The fever