Age-related risk factors and severity of SARS-CoV-2 infection: a systematic review and meta-analysis

30, July 2021 |

Authors:

Abstract

Objectives. We aimed to estimate the prevalence of reported symptoms and comorbidities, and investigate the factors associ- ated with age of the SARS-CoV-2 infected patients. Methods. We performed a systematic review with meta-analysis (PROSPERO registration: CRD42020182677) where the data- bases (PubMed, SCOPUS, EMBASE, WHO, Semantic Scholar, and COVID-19 Primer) were searched for clinical studies pub- lished from January to April, 2020. Initially, the pooled preva- lence of symptoms and comorbidity of COVID-19 patients were estimated using random effect model and the age –related fac- tors were identified performing multivariate analysis [factor analysis]. Results. Twenty-nine articles with 4,884 COVID-19 patients were included in this study. Altogether, we found 33 symptoms and 44 comorbidities where the most frequent 19 symptoms and 11 comorbidities were included in the meta-analysis. The fever