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depression COVID-19 severe acute respiratory syndrome coronavirus 2 recovery Bangladesh sleep-wake disorders

Published On: 05 February, 2021

COVID-19 Depression Anxiety Stress Insomnia Meta-analysis Health professionals

Published On: 07 July, 2021

coronavirus e‐health health policy health care service telehealth

Published On: 28 August, 2020

SARS-CoV-2 Prevaccination IgG Antibody

Published On: 27 January, 2022

Socialization School closure Coronavirus Bangladesh Urban

Published On: 10 November, 2021

COVID-19 psychological impact Insomnia Sleep problems Fear of COVID-19 GIS-Based nationwide study Bangladesh

Published On: 26 April, 2021

COVID-19 Asthma Respiratory distress Pathophysiology Medications Self-care Telehealth Risk Management

Published On: 05 February, 2022

Infection vaccination COVID-19 healthcare professional academic platform

Published On: 18 February, 2022

Gender differences COVID-19 adults Bangladesh

Published On: 12 January, 2022

SARS-CoV-2 Sequence Phylogeny Variant Mutation Bangladesh

Published On: 22 October, 2021

COVID‐19 Bangladesh

Published On: 26 January, 2022

COVID-19 Health care workers Personal protective equipment infection prevention control Bangladesh

Published On: 21 October, 2021

COVID-19 comorbidity medicinal plants Artemisia herba-alba molecular docking

Published On: 13 January, 2022

COVID-19 antimicrobial resistance consumption behavior antimicrobial stewardships community engagement Bangladesh

Published On: 28 January, 2022

SARS-CoV-2 COVID-19 pandemic Second wave Vaccines SARS-CoV-2 variants Host immunity Non- pharmaceutical interventions

Published On: 16 February, 2022

COVID-19 psychological impact depression anxiety internet use behaviors Bangladeshi students

Published On: 01 September, 2020

medical students depressive symptoms patient health questionnaire-(PHQ-9) COVID-19 Bangladesh

Published On: 31 January, 2022

SARS-CoV-2 COVID-19 neonates low- and middle-income country Bangladesh

Published On: 12 December, 2020

Mutation SARS-CoV-2 Molecular phylogeny Protein structure Frequency Bangladesh

Published On: 12 July, 2021

COVID-19 vaccine lifestyle attitude behavior post-vaccination

Published On: 21 January, 2022

Travel mode Risk perception COVID-19 Psychology Modal shift

Published On: 20 January, 2022

chemokines COVID‐19 cytokines disease severity proinflammatory molecules relative expression
Aggressive immune response, due to overexpressed proinflammatory molecules, has been characterized in coronavirus disease 2019 (COVID‐19) patients. Some of those mediators have a dual and opposite role on immune systems at play behind dif- ferential disease severities. We investigated the expression of some cytokines and chemokines in COVID‐19 patients in Bangladesh. We diagnosed the patients by detecting severe acute respiratory syndrome coronavirus 2 RNA in nasal swab samples by the real‐time RT‐PCR method. Thirty adult patients were preselected based on their disease severities and grouped into mild, moderate, and severe cases. Nine healthy volunteers participated in this study as a control. Relative expression of nine cytokines/chemokine in total leukocytes was semi‐quantified in SYBRgreen‐ based real‐time quantitative reverse‐transcriptase polymerase chain reaction. We performed statistical tests on transformed log data using SPSS 24.0. At the onset of symptoms (Day 1), angiotensin‐converting enzyme 2 (ACE2) (p < 0.05) and inter- leukin (IL)‐6 (p > 0.05) were upregulated in all COVID‐19 groups, although the ex- pression levels did not significantly correlate with disease severities. However, expressions of IL‐6, monocyte chemotactic protein‐1, macrophage inflammatory protein‐1α, tumor necrosis factor‐α (TNF‐α), RANTES (regulated upon activation, normal T cell expressed and secreted), and ACE2, on Day 14, were positively cor- related with disease severities. Relative viral load at Day 1 showed no significant correlation with cytokine expression but had a significant positive correlation with RANTES and ACE2 expression on Day 14 (p < 0.05). Male patients had a higher level of IL‐6 than female patients on Day 1 (p < 0.05). All COVID‐19 patients showed upregulated cytokines and chemokines on Day 14 compared to Day 1 except TNF‐α. Female patients had a higher expression of ACE2 and IL‐12 on Day 14. Upregulated cytokines/chemokines at the convalescent stage, especially IL‐6, may help in tar- geting anticytokine therapy in post‐COVID‐19 patients' management.

Published On: 29 May, 2021

Depression Anxiety Mental health COVID-19 Outbreak

Published On: 15 June, 2021

psychological distress fear coping COVID-19 Bangladesh dental mental health

Published On: 24 December, 2021

coronavirus mathematical prediction model pandemic (COVID-19) susceptible-infectious-recovered (SIR) model graphical trend analysis

Published On: 20 November, 2020

Mannose-specific/mannose-binding lectins Glycoprotein Glycosylation SARS-CoV-2 glycobiology Antiviral plant lectins Glycobiotechnology

Published On: 07 December, 2021

COVID-19 Perception Experiences Young adults Bangladesh

Published On: 28 June, 2021

Bangladesh COVID-19 developing countries parents pediatrics vaccine hesitancy

Published On: 02 March, 2022

NLRP3 inflammasome Immune response COVID-19 Risk factors Therapeutics

Published On: 25 November, 2021

Coronavirus variants COVID-19 pandemic delta variants public health healthcare challenge

Published On: 05 January, 2022

SARS-CoV-2 peptides RBD peptide-protein docking molecular dynamics

Published On: 27 January, 2022

COVID-19 expanded program on immunization (EPI) EPI outreach session (EOS) missing vaccine Chakaria Bangladesh

Published On: 17 January, 2022

antibiotics antimicrobial stewardship programs Bangladesh children COVID-19 guide- lines hospitals outcomes

Published On: 14 January, 2022

COVID-19 telehealth mental health Bangladesh

Published On: 22 March, 2021

COVID-19 Food security Nutrition security Food access One health Policy intervention

Published On: 21 December, 2021

Health system COVID-19 urban slum population Bangladesh

Published On: 04 February, 2022

Mental health & well-being COVID-19 Anxiety Gender Students

Published On: 08 February, 2022

Telehealth Gender disparity Health inequality Healthcare COVID-19 pandemic

Published On: 10 December, 2021

diagnostic performance specificity sensitivity rt-qpcr sars-cov-2 covid-19

Published On: 22 December, 2021

COVID-19 Bangladesh Disease characteristics serological responses

Published On: 04 January, 2022

COVID-19 SARS CoV-2 Chest CT RT-PCR Rapid antigen test

Published On: 21 June, 2021

SARS-CoV-2 Singleplex rRT-PCR Multiplex rRT-PCR Cost effective assay In-house kit Developing country

Published On: 21 April, 2021

Depression Anxiety COVID-19 pandemic University students Bangladesh

Published On: 25 November, 2021

COVID-19 pandemic SARS-COV-2 coronavirus reproduction number modelling infectious disease

Published On: 07 September, 2021

Plant extracts SARS-CoV-2 Antioxidant Cytotoxicity Receptor-binding Domain Molecular Dynamics Simulation

Published On: 01 December, 2021

CLAHE Convolutional Neural Network COVID19 Ensemble learning Feature scaling Guassian Naive Bayes Support Vector Machine Soft voting

Published On: 04 February, 2022

COVID-19 Clinical manifestations Second-wave Bangladesh Asymptomatic–symptomatic

Published On: 21 June, 2021

SARS-CoV-2 COVID-19 diagnostics rapid test PCR surveillance pandemic rapid antigen detection 2019 novel coronavirus

Published On: 08 December, 2021

COVID-19 SARS-CoV-2 biosafety laboratory challenges

Published On: 17 June, 2022